Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19

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Liu, Shiyu, Luo, Wenjuan, Szatmary, Peter ORCID: 0000-0002-7454-9851, Zhang, Xiaoying, Lin, Jing-Wen, Chen, Lu, Liu, Dan, Sutton, Robert ORCID: 0000-0001-6600-562X, Xia, Qing, Jin, Tao et al (show 2 more authors) , Liu, Tingting and Huang, Wei (2023) Monocytic HLA-DR Expression in Immune Responses of Acute Pancreatitis and COVID-19. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (4). 3246-.

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Official URL: http://dx.doi.org/10.3390/ijms24043246

Abstract

Acute pancreatitis is a common gastrointestinal disease with increasing incidence worldwide. COVID-19 is a potentially life-threatening contagious disease spread throughout the world, caused by severe acute respiratory syndrome coronavirus 2. More severe forms of both diseases exhibit commonalities with dysregulated immune responses resulting in amplified inflammation and susceptibility to infection. Human leucocyte antigen (HLA)-DR, expressed on antigen-presenting cells, acts as an indicator of immune function. Research advances have highlighted the predictive values of monocytic HLA-DR (mHLA-DR) expression for disease severity and infectious complications in both acute pancreatitis and COVID-19 patients. While the regulatory mechanism of altered mHLA-DR expression remains unclear, HLA-DR<sup>-/low</sup> monocytic myeloid-derived suppressor cells are potent drivers of immunosuppression and poor outcomes in these diseases. Future studies with mHLA-DR-guided enrollment or targeted immunotherapy are warranted in more severe cases of patients with acute pancreatitis and COVID-19.

Item Type:	Article
Uncontrolled Keywords:	acute pancreatitis, COVID-19, HLA-DR, monocytes, immune response, immunosuppression
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	18 Apr 2023 08:38
Last Modified:	18 Apr 2023 08:38
DOI:	10.3390/ijms24043246
Open Access URL:	https://doi.org/10.3390/ijms24043246
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169645