Abouyannis, Michael, Esmail, Hanif, Hamaluba, Mainga, Ngama, Mwanajuma, Mwangudzah, Hope, Mumba, Noni, Yeri, Betty K, Mwalukore, Salim, Alphan, Hassan J, Aggarwal, Dinesh et al (show 16 more authors)
(2023)
A global core outcome measurement set for snakebite clinical trials.
LANCET GLOBAL HEALTH, 11 (2).
E296-E300.
Abstract
Snakebite clinical trials have often used heterogeneous outcome measures and there is an urgent need for standardisation. A globally representative group of key stakeholders came together to reach consensus on a globally relevant set of core outcome measurements. Outcome domains and outcome measurement instruments were identified through searching the literature and a systematic review of snakebite clinical trials. Outcome domains were shortlisted by use of a questionnaire and consensus was reached among stakeholders and the patient group through facilitated discussions and voting. Five universal core outcome measures should be included in all future snakebite clinical trials-mortality, WHO disability assessment scale, patient-specific functional scale, acute allergic reaction by Brown criteria, and serum sickness by formal criteria. Additional syndrome-specific core outcome measures should be used depending on the biting species. This core outcome measurement set provides global standardisation, supports the priorities of patients and clinicians, enables meta-analysis, and is appropriate for use in low-income and middle-income settings.
Item Type: | Article |
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Uncontrolled Keywords: | Snakebite Global Core Outcome Set Study Group, Humans, Snake Bites, Treatment Outcome, Consensus, Clinical Trials as Topic, Global Health, Surveys and Questionnaires, Outcome Assessment, Health Care |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 18 Apr 2023 13:59 |
Last Modified: | 31 Oct 2023 20:50 |
DOI: | 10.1016/S2214-109X(22)00479-X |
Open Access URL: | https://doi.org/10.1016/S2214-109X(22)00479-X |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3169698 |