Assessment of Antifungal Pharmacodynamics

Howard, Alex ORCID: 0000-0002-4195-6821 and Hope, William ORCID: 0000-0001-6187-878X (2023) Assessment of Antifungal Pharmacodynamics. JOURNAL OF FUNGI, 9 (2). 192-.

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Official URL: http://dx.doi.org/10.3390/jof9020192

Abstract

Pharmacokinetic-pharmacodynamic (PK-PD) analysis is of central importance to the progress of an antifungal agent into clinical use. It is crucial to ensure that preclinical studies give the best possible prediction of the way drugs are likely to behave in a clinical setting. This review details the last 30 years of progress in terms of disease model design, efficacy outcome selection and translational modelling in antifungal PK-PD studies. The principles of how PK-PD parameters inform current clinical practice are also discussed, including a review of how these apply to existing and novel agents.

Item Type:	Article
Uncontrolled Keywords:	antifungal, pharmacokinetics, pharmacodynamics, translational, clinical, efficacy, animal
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	19 Apr 2023 10:13
Last Modified:	19 Apr 2023 10:13
DOI:	10.3390/jof9020192
Open Access URL:	https://doi.org/10.3390/jof9020192
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169742