Experimental infection of tick cells with Nipah virus

Phoon, WH, Bell-Sakyi, L ORCID: 0000-0002-7305-0477, AbuBakar, S and Chang, LY (2023) Experimental infection of tick cells with Nipah virus. TROPICAL BIOMEDICINE, 40 (1). pp. 29-36.

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Abstract

Nipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tick cells and ultrastructural features of NiV were observed by electron microscopy. These results suggest that ticks could support NiV infection, potentially playing a role in transmission.

Item Type:	Article
Uncontrolled Keywords:	Henipavirus infection, Chiroptera, ticks, viral RNA, electron microscopy
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	02 May 2023 07:43
Last Modified:	26 Jul 2023 16:28
DOI:	10.47665/tb.40.1.009
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3169918