Functional crosstalk between chromatin and hypoxia signalling

Collier, Harry, Albanese, Adam, Kwok, Chun-Sui, Kou, Jiahua and Rocha, Sonia (2023) Functional crosstalk between chromatin and hypoxia signalling. CELLULAR SIGNALLING, 106. 110660-.

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Abstract

Eukaryotic genomes are organised in a structure called chromatin, comprising of DNA and histone proteins. Chromatin is thus a fundamental regulator of gene expression, as it offers storage and protection but also controls accessibility to DNA. Sensing and responding to reductions in oxygen availability (hypoxia) have recognised importance in both physiological and pathological processes in multicellular organisms. One of the main mechanisms controlling these responses is control of gene expression. Recent findings in the field of hypoxia have highlighted how oxygen and chromatin are intricately linked. This review will focus on mechanisms controlling chromatin in hypoxia, including chromatin regulators such as histone modifications and chromatin remodellers. It will also highlight how these are integrated with hypoxia inducible factors and the knowledge gaps that persist.

Item Type:	Article
Uncontrolled Keywords:	Hypoxia, Chromatin, HIF, HAT, HDAC, KDM, HMT, Chromatin remodellers, Acetylation, Methylation
Divisions:	Faculty of Health and Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	25 May 2023 09:35
Last Modified:	25 May 2023 09:35
DOI:	10.1016/j.cellsig.2023.110660
Open Access URL:	https://doi.org/10.1016/j.cellsig.2023.110660
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3170654