Dhirachaikulpanich, Dhanach 
ORCID: 0000-0003-2234-1837, Madhusudhan, Savita, Parry, David ORCID: 0000-0002-9114-774X, Babiker, Salma, Zheng, Yalin ORCID: 0000-0002-7873-0922 and Beare, Nicholas AV ORCID: 0000-0001-8086-990X
(2023)
RETINAL VASCULITIS SEVERITY ASSESSMENT Intraobserver and Interobserver Reliability of a New Scheme for Grading Wide-Field Fluorescein Angiograms in Retinal Vasculitis.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 43 (9).
pp. 1534-1543.
Abstract
<h4>Purpose</h4>Wide-field fluorescein angiography is commonly used to assess retinal vasculitis (RV), which manifests as vascular leakage and occlusion. Currently, there is no standard grading scheme for RV severity. The authors propose a novel RV grading scheme and assess its reliability and reproducibility.<h4>Methods</h4>A grading scheme was developed to assess both leakage and occlusion in RV. Wide-field fluorescein angiography images from 50 patients with RV were graded by four graders, and one grader graded them twice. An intraclass correlation coefficient (ICC) was used to determine intraobserver-interobserver reliability. Generalized linear models were calculated to associate the scoring with visual acuity.<h4>Results</h4>Repeated grading by the same grader showed good intraobserver reliability for both leakage (ICC = 0.85, 95% CI 0.78-0.89) and occlusion (ICC = 0.82, 95% CI 0.75-0.88) scores. Interobserver reliability among four independent graders showed good agreement for both leakage (ICC = 0.66, 95% CI 0.49-0.77) and occlusion (ICC = 0.75, 95% CI 0.68-0.81) scores. An increasing leakage score was significantly associated with worse concurrent visual acuity (generalized linear models, β = 0.090, P < 0.01) and at 1-year follow-up (generalized linear models, β = 0.063, P < 0.01).<h4>Conclusion</h4>The proposed grading scheme for RV has good to excellent intraobserver and interobserver reliability across a range of graders. The leakage score related to present and future visual acuity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cystoid macular edema, fluorescein angiography, optic disk leakage, posterior uveitis, retinal vascular leakage, retinal vascular occlusion, retinal vasculitis, visual acuity |
| Divisions: | Faculty of Health and Life Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Jun 2023 09:38 |
| Last Modified: | 15 Mar 2024 06:34 |
| DOI: | 10.1097/IAE.0000000000003838 |
| Open Access URL: | http://10.0.4.73/IAE.0000000000003838 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3170776 |
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