Violi, Francesco, Ceccarelli, Giancarlo, Cangemi, Roberto, Cipollone, Francesco, D'Ardes, Damiano, Oliva, Alessandra, Pirro, Matteo, Rocco, Monica, Alessandri, Francesco, D'Ettorre, Gabriella et al (show 7 more authors)
(2021)
Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19): relationship with mortality.
INTERNAL AND EMERGENCY MEDICINE, 16 (5).
pp. 1231-1237.
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Abstract
<h4>Background</h4>Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse.<h4>Methods</h4>Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered.<h4>Results</h4>Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8-12.6; p < 0.001); coronary artery disease (OR: 2.4; 95% CI 1.4-5.0; p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28-0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59-4.65; p < 0.001), age (HR: 1.035; 95% CI 1.014-1.057; p = 0.001), and albumin (HR: 0.447; 95% CI 0.277-0.723; p = 0.001) predicted morality.<h4>Conclusions</h4>Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Covid-19, SARS-cov-2, Thrombosis, Mortality |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 10 Aug 2023 13:47 |
| Last Modified: | 10 Aug 2023 13:47 |
| DOI: | 10.1007/s11739-020-02621-8 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3172137 |
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