Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Nicholas-Haizelden, Keir, Murphy, Barry, Hoptroff, Michael and Horsburgh, Malcolm J ORCID: 0000-0002-3806-0039 (2023) Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products. Microorganisms, 11 (8). p. 1899.

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Abstract

<jats:p>Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays applicative potential. Studies elucidating the organismal interfaces and concomitant understanding of the central processes of skin biology have begun to unravel a potential wealth of molecules which can exploited for their proposed functions. A variety of skin-microbiome-derived compounds display prospective therapeutic applications, ranging from antioncogenic agents relevant in skin cancer therapy to treatment strategies for antimicrobial-resistant bacterial and fungal infections. Considerable opportunities have emerged for the translation to personal care products, such as topical agents to mitigate various skin conditions such as acne and eczema. Adjacent compound developments have focused on cosmetic applications such as reducing skin ageing and its associated changes to skin properties and the microbiome. The skin microbiome contains a wealth of prospective compounds with therapeutic and commercial applications; however, considerable work is required for the translation of in vitro findings to relevant in vivo models to ensure translatability.</jats:p>

Item Type:	Article
Uncontrolled Keywords:	skin microbiome, therapeutics, bioprospecting, personal care, ageing, lipid
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	29 Aug 2023 10:42
Last Modified:	13 Sep 2023 15:19
DOI:	10.3390/microorganisms11081899
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3172392