Simons, Paula, Lyons, Bridget, Bentley, Adrienne, Mazzaferro, Elisa, Thalheim, Lindsay, Finotello, Riccardo and Ressel, Lorenzo 
ORCID: 0000-0002-6614-1223
(2023)
Case report: Severe, refractory hypoglycemia in a 9-year-old Brittany Spaniel with renal nephroblastoma.
FRONTIERS IN VETERINARY SCIENCE, 10.
1116846-.
Abstract
A 9-year-old female spayed Brittany Spaniel presented for weakness and stumbling, and was diagnosed with severe hypoglycemia. An insulin to glucose ratio was not consistent with insulinoma as a cause for hypoglycemia. Diagnostic imaging (abdominal ultrasound and computed tomography) revealed a large left renal mass and a possible metastatic lesion in the right kidney. Glucagon therapy was initiated, but hypoglycemia was refractory to therapy. A left nephrectomy was performed and hypoglycemia subsequently resolved. Histopathology of the mass was consistent with nephroblastoma and immunohistochemistry for anti-insulin-like Growth Factor-2 (IGF-2) antibody revealed immunoreactivity in over 50% of the neoplastic cells. Chemotherapeutic treatment was initiated with a combined protocol of vincristine and doxorubicin. To the authors' knowledge, this is the first case report documenting the treatment of severe, refractory non-islet cell tumor-induced hypoglycemia in a dog, suspected to be secondary to an IGF-2 secreting nephroblastoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | glucagon, hypoglycemia, nephrectomy, nephroblastoma, non-islet cell tumor-induced hypoglycemia (NICTH), oncology |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 05 Oct 2023 10:10 |
| Last Modified: | 05 Oct 2023 11:43 |
| DOI: | 10.3389/fvets.2023.1116846 |
| Open Access URL: | https://doi.org/10.3389/fvets.2023.1116846 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173445 |
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