Clinical Outcomes of Observed and Treated Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis

Steptoe, Paul J, Pearce, Ian, Beare, Nicholas AV ORCID: 0000-0001-8086-990X, Sreekantham, Sreekanth, Mohammed, Bashar R, Barry, Robert J, Denniston, Alastair K and Murray, Philip I (2023) Clinical Outcomes of Observed and Treated Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis. OCULAR IMMUNOLOGY AND INFLAMMATION, ahead- (ahead-). pp. 1-7.

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Official URL: http://dx.doi.org/10.1080/09273948.2023.2195934

Abstract

<h4>Purpose</h4>To assess the efficacy of treatment on acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinopathy (RPC).<h4>Methods</h4>Cases were identified from three UK uveitis centers. Retrospective analysis of visual acuity recovery; OCT structural outcomes; and retinal lesion quantification in observed and treated cases of APMPPE/RPC.<h4>Results</h4>There were nine APMPPE and three RPC cases. Out of 12 patients, six were female. Median age: 26.5 years (range, 20-57 years). Four cases (six eyes) were observed, and eight cases (15 eyes) received corticosteroids ± immunosuppression. 4/4 observed and 6/10 treated foveal involving eyes regained 0.00 LogMAR vision. Observed lesions achieved more favorable anatomical outcomes. New lesions post-presentation developed in 1/6 (16%) observed eye versus 10/15 (66%) treated eyes. In three cases, a delayed, rebound lesion occurrence was observed post-high-dose corticosteroids.<h4>Conclusions</h4>While subject to potential treatment bias, in this small case series, natural history alone appears non-inferior to corticosteroid treatment.

Item Type:	Article
Uncontrolled Keywords:	Acute posterior multifocal placoid pigment epitheliopathy (APMPPE), relentless placoid chorioretinitis (RPC), angular sign of Henle fibre layer hyperreflectivity (ASHH), Bacillary Layer Detachment (BALAD)
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	05 Oct 2023 12:55
Last Modified:	14 Mar 2024 18:01
DOI:	10.1080/09273948.2023.2195934
Open Access URL:	https://doi.org/10.1080/09273948.2023.2195934
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3173453