Wolf, Adam, Khimani, Faria 
ORCID: 0000-0003-4828-4711, Yoon, Braian, Gerhart, Coltin, Endsley, Dakota, Ray, Anish K, Yango, Angelito F, Flynn, Stuart D, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Gonzalez, Stevan A et al (show 1 more authors)
(2022)
The mechanistic basis linking cytokine storm to thrombosis in COVID-19.
Thrombosis update, 8.
100110-.
Abstract
It is now well established that infection with SARS-CoV-2 resulting in COVID-19 disease includes a severely symptomatic subset of patients in whom an aggressive and/or dysregulated host immune response leads to cytokine storm syndrome (CSS) that may be further complicated by thrombotic events, contributing to the severe morbidity and mortality observed in COVID-19. This review provides a brief overview of cytokine storm in COVID-19, and then presents a mechanistic discussion of how cytokine storm affects integrated pathways in thrombosis involving the endothelium, platelets, the coagulation cascade, eicosanoids, auto-antibody mediated thrombosis, and the fibrinolytic system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19, Clots, Coagulopathy, Cytokine storm, SARS-CoV2, Thrombosis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Oct 2023 13:40 |
| Last Modified: | 27 Apr 2024 23:38 |
| DOI: | 10.1016/j.tru.2022.100110 |
| Open Access URL: | https://doi.org/10.1016/j.tru.2022.100110 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3173554 |
Dimensions
Dimensions
