The role of autophagy in hypoxia-induced radioresistance.

Hill, Rhianna Mae, Fok, Matthew, Grundy, Gabrielle, Parsons, Jason Luke and Rocha, Sonia (2023) The role of autophagy in hypoxia-induced radioresistance. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 189. 109951-.

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Official URL: http://dx.doi.org/10.1016/j.radonc.2023.109951

Abstract

Radiotherapy is a widely used treatment modality against cancer, and although survival rates are increasing, radioresistant properties of tumours remain a significant barrier for curative treatment. Tumour hypoxia is one of the main contributors to radioresistance and is common in most solid tumours. Hypoxia is responsible for many molecular changes within the cell which helps tumours to survive under such challenging conditions. These hypoxia-induced molecular changes are predominantly coordinated by the hypoxia inducible factor (HIF) and have been linked with the ability to confer resistance to radiation-induced cell death. To overcome this obstacle research has been directed towards autophagy, a cellular process involved in self degradation and recycling of macromolecules, as HIF plays a large role in its coordination under hypoxic conditions. The role that autophagy has following radiotherapy treatment is conflicted with evidence of both cytoprotective and cytotoxic effects. This literature review aims to explore the intricate relationship between radiotherapy, hypoxia, and autophagy in the context of cancer treatment. It provides valuable insights into the potential of targeting autophagy as a therapeutic strategy to improve the response of hypoxic tumours to radiotherapy.

Item Type:	Article
Uncontrolled Keywords:	Cell Line, Tumor, Humans, Neoplasms, Cell Hypoxia, Radiation Tolerance, Autophagy, Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	18 Oct 2023 12:50
Last Modified:	08 Dec 2023 14:20
DOI:	10.1016/j.radonc.2023.109951
Open Access URL:	https://doi.org/10.1016/j.radonc.2023.109951
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3173853