Senior, JM 
ORCID: 0000-0002-9425-9261
(2008)
'Complement and Endotoxins in equine colic'.
PhD thesis, University of Liverpool.
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Abstract
Colic (abdominal pain) is a relatively common disease of horses ranging from mild, transient episodes to a life-threatening syndrome that requires surgical intervention. Equine intestinal abnormalities that involve local stasis are often accompanied by marked proliferation of Gram negative enteric bacteria and breakdown of the mucosal barrier resulting in the transmural and transvascular migration of bacteria and their endotoxins into the circulation (endotoxaemia). Even if the original cause of colic is corrected or resolved, the presence of endotoxaemia can isult in significant morbidity and mortality in horses. This project aimed to characterise specific equine complement component, complement 1 esterase-inhibitor (Cl-inh) because it is considered a key inhibitor of the connplement, coagulation and contact activation pathways.
| Item Type: | Thesis (PhD) |
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| Uncontrolled Keywords: | horse, colic, endotoxin, complement |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Oct 2023 09:24 |
| Last Modified: | 20 Oct 2023 09:58 |
| DOI: | 10.17638/03174432 |
| Copyright Statement: | Copyright © and Moral Rights for this thesis and any accompanying data (where applicable) are retained by the author and/or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3174432 |
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