Badgery, Henry E, Muhlen-Schulte, Tjuntu, Zalcberg, John R 
ORCID: 0000-0002-6624-0782, D'souza, Bianka, Gerstenmaier, Jan F, Pickett, Craig ORCID: 0000-0003-0629-7928, Samra, Jaswinder, Croagh, Daniel ORCID: 0000-0002-6430-6741 and Pancreatic Cancer Image Biobank Authorship Group,
(2023)
Determination of "borderline resectable" pancreatic cancer - A global assessment of 30 shades of grey.
HPB : the official journal of the International Hepato Pancreato Biliary Association, 25 (11).
pp. 1393-1401.
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Abstract
<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor prognosis. Accurate preoperative assessment using computed tomography (CT) to determine resectability is crucial in ensuring patients are offered the most appropriate therapeutic strategy. Despite the use of classification guidelines, any interobserver variability between reviewing surgeons and radiologists may confound decisions influencing patient treatment pathways.<h4>Methods</h4>In this multicentre observational study, an international group of 96 clinicians (42 hepatopancreatobiliary surgeons and 54 radiologists) were surveyed and asked to report 30 pancreatic CT scans of pancreatic cancer deemed borderline at respective multidisciplinary meetings (MDM). The degree of interobserver agreement in resectability among radiologists and surgeons was assessed and subgroup regression analysis was performed.<h4>Results</h4>Interobserver variability between reviewers was high with no unanimous agreement. Overall interobserver agreement was fair with a kappa value of 0.32 with a higher rate of agreement among radiologists over surgeons.<h4>Conclusion</h4>Interobserver variability among radiologists and surgeons globally is high, calling into question the consistency of clinical decision making for patients with PDAC and suggesting that central review may be required for studies of neoadjuvant or adjuvant approaches in future as well as ongoing quality control initiatives, even amongst experts in the field.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Pancreatic Cancer Image Biobank Authorship Group, Humans, Adenocarcinoma, Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms, Tomography, X-Ray Computed, Neoadjuvant Therapy |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 06 Nov 2023 16:25 |
| Last Modified: | 23 Feb 2024 10:15 |
| DOI: | 10.1016/j.hpb.2023.07.883 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3176654 |
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