Zhu, Jingjing and Wilding, John PH 
ORCID: 0000-0003-2839-8404
(2023)
Body Fat Depletion: the Yin Paradigm for Treating Type 2 Diabetes.
Current atherosclerosis reports, 26 (1).
pp. 1-10.
Abstract
<h4>Purpose of review</h4>To highlight that body fat depletion (the Yin paradigm) with glucose-lowering treatments (the Yang paradigm) are associated with metabolic benefits for patients with type 2 diabetes mellitus (T2DM).<h4>Recent findings</h4>The sodium-glucose cotransporter-2 inhibitor-mediated sodium/glucose deprivation can directly improve glycemic control and kidney outcome in patients with T2DM. The glucose deprivation might also promote systemic fatty acid β-oxidation to deplete ectopic/visceral fat and thereby contribute to the prevention of cardiovascular diseases. As with metabolic surgery, bioengineered incretin-based medications with potent anorexigenic and insulinotropic efficacy can significantly reduce blood glucose as well as body weight (especially in the ectopic/visceral fat depots). The latter effects could be a key contributor to their cardiovascular-renal protective effects. In addition to a healthy diet, the newer glucose-lowering medications, with body fat reduction effects, should be prioritized when treating patients with T2DM, especially for those with established cardiovascular/renal risks or diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Adipose Tissue, Humans, Diabetes Mellitus, Type 2, Sodium, Glucose, Hypoglycemic Agents, Sodium-Glucose Transporter 2 Inhibitors |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 19 Jan 2024 11:21 |
| Last Modified: | 02 Feb 2024 17:06 |
| DOI: | 10.1007/s11883-023-01181-4 |
| Open Access URL: | https://doi.org/10.1007/s11883-023-01181-4 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3177910 |
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