Williams, Sydney, Qi, Leiming, Cox, Robert J, Kumar, Prashant and Xiao, Jianliang ORCID: 0000-0003-2010-247X
(2024)
Hydrogenation of functionalised pyridines with a rhodium oxide catalyst under mild conditions.
Organic & biomolecular chemistry, 22 (5).
pp. 1010-1017.
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Abstract
Piperidines are one of the most widely used building blocks in the synthesis of pharmaceutical and agrochemical compounds. The hydrogenation of pyridines is a convenient method to synthesise such compounds as it only requires reactant, catalyst, and a hydrogen source. However, this reaction still remains difficult for the reduction of functionalised and multi-substituted pyridines. Here we report the use of a stable, commercially available rhodium compound, Rh<sub>2</sub>O<sub>3</sub>, for the reduction of various unprotected pyridines. The reaction only requires mild conditions, and the substrate scope is broad, making it practically useful.
Item Type: | Article |
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Divisions: | Faculty of Science and Engineering > School of Physical Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 26 Jan 2024 08:13 |
Last Modified: | 03 Feb 2024 02:07 |
DOI: | 10.1039/d3ob01860a |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178040 |