Buzibye, Allan, Wools-Kaloustian, Kara, Olagunju, Adeniyi 
ORCID: 0000-0002-6588-5749, Twinomuhwezi, Ellon, Yiannoutsos, Constantin, Owen, Andrew, Neary, Megan ORCID: 0000-0002-4960-2139, Matovu, Joshua, Banturaki, Grace, Castelnuovo, Barbara et al (show 4 more authors)
(2023)
Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study.
AIDS research and therapy, 20 (1).
p. 20.
Abstract
<h4>Background</h4>We investigated the association between CYP2B6 polymorphisms and efavirenz drug resistance among women living with HIV who started on antiretroviral therapy during pregnancy and with high viremia during post-partum.<h4>Methods</h4>This was a cross-sectional study of women with viral loads greater than 1000 copies/ml who were at least 6 weeks postpartum. Sanger sequencing was used to detect resistant mutations, as well as host genotyping, and efavirenz resistance was compared among the metabolizer genotypes.<h4>Results</h4>Over the course of one year (July 2017-July 2018), 322 women were screened, with 110 (34.2%) having viral loads of 1000 copies/ml and 62 having whole blood available for genotyping. Fifty-nine of these women had both viral resistance and human host genotypic results. Efavirenz resistance according to metabolizer genotype was; 47% in slow, 34% in extensive and 28% in intermediate metabolizers, but the difference was not statistically significant due to the small sample size.<h4>Conclusions</h4>There was no statistically significant difference in EFV resistance between EFV metabolizer genotypes in women who started antiretroviral therapy during pregnancy and had high viremia in the postpartum period. However, a numerical trend was discovered, which calls for confirmation in a large, well-designed, statistically powered study.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Viremia, HIV Infections, Benzoxazines, Anti-HIV Agents, Cross-Sectional Studies, Postpartum Period, Pregnancy, Genotype, Polymorphism, Single Nucleotide, Uganda, Female, Cytochrome P-450 CYP2B6 |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Feb 2024 11:40 |
| Last Modified: | 02 Feb 2024 11:40 |
| DOI: | 10.1186/s12981-023-00514-2 |
| Open Access URL: | https://doi.org/10.1186/s12981-023-00514-2 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3178333 |
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