Costigan, Dana, Fenn, Joe, Yen, Sandi, Ilott, Nicholas, Bullers, Samuel, Hale, Jessica, Greenhalf, William 
ORCID: 0000-0002-1865-3195, Conibear, Emily, Koycheva, Aleksandra, Madon, Kieran et al (show 18 more authors)
(2024)
A pro-inflammatory gut mucosal cytokine response is associated with mild COVID-19 disease and superior induction of serum antibodies.
Mucosal immunology, 17 (1).
pp. 111-123.
Abstract
The relationship between gastrointestinal tract infection, the host immune response, and the clinical outcome of disease is not well understood in COVID-19. We sought to understand the effect of intestinal immune responses to SARS-CoV-2 on patient outcomes including the magnitude of systemic antibody induction. Combining two prospective cohort studies, International Severe Acute Respiratory and emerging Infections Consortium Comprehensive Clinical Characterisations Collaboration (ISARIC4C) and Integrated Network for Surveillance, Trials and Investigations into COVID-19 Transmission (INSTINCT), we acquired samples from 88 COVID-19 cases representing the full spectrum of disease severity and analysed viral RNA and host gut cytokine responses in the context of clinical and virological outcome measures. There was no correlation between the upper respiratory tract and faecal viral loads. Using hierarchical clustering, we identified a group of fecal cytokines including Interleukin-17A, Granulocyte macrophage colony-stimulating factor, Tumor necrosis factorα, Interleukin-23, and S100A8, that were transiently elevated in mild cases and also correlated with the magnitude of systemic anti-Spike-receptor-binding domain antibody induction. Receiver operating characteristic curve analysis showed that expression of these gut cytokines at study enrolment in hospitalised COVID-19 cases was associated negatively with overall clinical severity implicating a protective role in COVID-19. This suggests that a productive intestinal immune response may be beneficial in the response to a respiratory pathogen and a biomarker of a successful barrier response.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSTINCT Study Group, ISARIC4C investigators |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 13 Mar 2024 09:24 |
| Last Modified: | 13 Mar 2024 09:24 |
| DOI: | 10.1016/j.mucimm.2023.11.005 |
| Open Access URL: | https://doi.org/10.1016/j.mucimm.2023.11.005 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179361 |
Dimensions
Dimensions
