Sacco, Joseph J, Jackson, Richard, Corrie, Pippa, Danson, Sarah, Jeffry Evans, TR, Ochsenreither, Sebastian, Kumar, Satish, Goodman, Andrew, Larkin, James, Karydis, Ioannis et al (show 11 more authors)
(2024)
A three-arm randomised Phase II study of the MEK inhibitor selumetinib alone or in combination with paclitaxel in metastatic uveal melanoma.
European Journal of Cancer, 202.
p. 114009.
Abstract
<h4>Aims</h4>The MAPK pathway is constitutively activated in uveal melanoma (UM). Selumetinib (AZD6244, ARRY-142886), a MEK inhibitor, has shown limited activity as monotherapy in metastatic UM. Pre-clinical studies support synergistic cytotoxic activity for MEK inhibitors combined with taxanes, and here we sought to assess the clinical efficacy of combining selumetinib and paclitaxel.<h4>Patients and methods</h4>Seventy-seven patients with metastatic UM who had not received prior chemotherapy were randomised to selumetinib alone, or combined with paclitaxel with or without interruption in selumetinib two days before paclitaxel. The primary endpoint was progression free survival (PFS). After amendment, the combination arms were combined for analysis and the sample size adjusted to detect a hazard ratio (HR): 0.55, 80% power at 1-sided 5% significance level.<h4>Results</h4>The median PFS in the combination arms was 4.8 months (95% CI: 3.8 - 5.6) compared with 3.4 months (2.0 - 3.9) in the selumetinib arm (HR 0.62 [90% CI 0.41 - 0.92], 1-sided p-value = 0.022). ORR was 14% and 4% in the combination and monotherapy arms respectively. Median OS was 9 months for the combination and was not significantly different from selumetinib alone (10 months) with HR of 0.98 [90% CI 0.58 - 1.66], 1-sided p-value = 0.469. Toxicity was in keeping with the known profiles of the agents involved.<h4>Conclusions</h4>SelPac met its primary endpoint, demonstrating an improvement in PFS for combination selumetinib and paclitaxel. No improvement in OS was observed, and the modest improvement in PFS is not practice changing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEK inhibitor, Metastatic uveal melanoma, Paclitaxel, Selumetinib |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 25 Mar 2024 08:34 |
| Last Modified: | 05 Apr 2024 13:49 |
| DOI: | 10.1016/j.ejca.2024.114009 |
| Open Access URL: | https://www.ejcancer.com/article/S0959-8049(24)001... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3179849 |
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