Impact of components of metabolic syndrome on the risk of adverse renal outcomes in patients with atrial fibrillation: a nationwide cohort study.

Kwon, Soonil, Lee, So-Ryoung, Choi, Eue-Keun, Lee, Seung-Woo, Jung, Jin-Hyung, Han, Kyung-Do, Ahn, Hyo-Jeong, Oh, Seil and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2023) Impact of components of metabolic syndrome on the risk of adverse renal outcomes in patients with atrial fibrillation: a nationwide cohort study. Frontiers in cardiovascular medicine, 10. p. 1208979.

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Official URL: http://dx.doi.org/10.3389/fcvm.2023.1208979

Abstract

<h4>Background</h4>The renal effect of metabolic syndrome components is unclear in patients with atrial fibrillation. This study aimed to investigate the association between metabolic syndrome components and incident end-stage renal disease among patients with atrial fibrillation.<h4>Methods</h4>A total of 202,434 atrial fibrillation patients without prevalent end-stage renal disease were identified from the National Health Insurance Service database between 2009 and 2016. We defined the metabolic score range from 0 to 5 points such that a patient received every 1 point if the patient met each component listed in the diagnostic criteria of metabolic syndrome. The population was divided into 6 groups: MS<sub>0</sub>-MS<sub>5</sub> for a metabolic score of 0-5, respectively. Multivariate Cox regression analysis was used to estimate the risks of end-stage renal disease.<h4>Results</h4>There were 12,747, 31,059, 40,361, 48,068, 46,630, and 23,569 patients for MS<sub>0</sub>-MS<sub>5</sub>, respectively. Compared with MS<sub>0</sub>, MS<sub>5</sub> had a higher CHA<sub>2</sub>DS<sub>2</sub>-VASc score (3.8 vs. 1.0) (<i>P</i> < .001). During a median follow-up of 3.5 years, compared with MS<sub>0</sub>, MS<sub>1</sub>-MS<sub>5</sub> were associated with a gradually increasing incidence of end-stage renal disease, in relation to an increase in the metabolic score, (log-rank <i>P</i> < .001). After multivariate adjustment, a higher metabolic score was associated with a greater risk of incident end-stage renal disease: adjusted hazard ratio [95% confidence interval] = 1.60 [0.78-3.48], 2.08 [1.01-4.31], 2.94 [1.43-6.06], 3.71 [1.80-7.66], and 4.82 [2.29-10.15], for MS<sub>1</sub>-MS<sub>5</sub>, respectively.<h4>Conclusions</h4>Metabolic syndrome components additively impacts the risk of incident end-stage renal disease among patients with atrial fibrillation.

Item Type:	Article
Uncontrolled Keywords:	atrial fibrillation, end-stage renal disease, epidemiology, metabolic syndrome, risk factor
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	26 Mar 2024 10:54
Last Modified:	26 Mar 2024 15:30
DOI:	10.3389/fcvm.2023.1208979
Open Access URL:	https://doi.org/10.3389/fcvm.2023.1208979
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179961