Musvosvi, Munyaradzi, Huang, Huang, Wang, Chunlin, Xia, Qiong, Rozot, Virginie, Krishnan, Akshaya, Acs, Peter, Cheruku, Abhilasha, Obermoser, Gerlinde, Leslie, Alasdair et al (show 11 more authors)
(2023)
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection.
Nature medicine, 29 (1).
pp. 258-269.
Abstract
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against Mycobacterium tuberculosis, but the ability to broadly study these responses has been limited. In the present study, we used single-cell and bulk T cell receptor (TCR) sequencing and the GLIPH2 algorithm to analyze M. tuberculosis-specific sequences in two longitudinal cohorts, comprising 166 individuals with M. tuberculosis infection who progressed to either tuberculosis (n = 48) or controlled infection (n = 118). We found 24 T cell groups with similar TCR-β sequences, predicted by GLIPH2 to have common TCR specificities, which were associated with control of infection (n = 17), and others that were associated with progression to disease (n = 7). Using a genome-wide M. tuberculosis antigen screen, we identified peptides targeted by T cell similarity groups enriched either in controllers or in progressors. We propose that antigens recognized by T cell similarity groups associated with control of infection can be considered as high-priority targets for future vaccine development.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Adolescent Cohort Study team, GC6-74 Consortium |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Apr 2024 10:04 |
| Last Modified: | 09 Apr 2024 13:55 |
| DOI: | 10.1038/s41591-022-02110-9 |
| Open Access URL: | https://doi.org/10.1038/s41591-022-02110-9 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180217 |
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