Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis.

Prokopidis, Konstantinos ORCID: 0000-0002-6264-9388, Morwani-Mangnani, Jordi, McDowell, Garry ORCID: 0000-0002-2880-5236, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Venturelli, Massimo, Sankaranarayanan, Rajiv ORCID: 0000-0003-2355-2011 and Isanejad, Masoud ORCID: 0000-0002-3720-5152 (2024) Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis. European geriatric medicine. pp. 1-9.

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Official URL: http://dx.doi.org/10.1007/s41999-024-00950-x

Abstract

<h4>Aims</h4>Sarcopenia is linked to impaired physical function and exercise tolerance. The aim of this systematic review and meta-analysis was to examine the association of sarcopenia and low appendicular skeletal muscle (ASM) with biomarkers of cardiac function, B-type natriuretic peptide (BNP) and its N-terminal fragment (NT-proBNP), in patients with heart failure (HF).<h4>Methods and results</h4>From inception until May 2023, a systematic literature search of observational studies was undertaken utilizing the PubMed, Web of Science, Scopus, and Cochrane Library databases. A meta-analysis employing a random-effects model was used to compute the pooled effects (CRD42023418465). Overall, 16 studies were included in this systematic review and meta-analysis. Our main analysis showed that sarcopenia in HF was linked to significantly higher levels of BNP (MD: 87.76, 95% CI 20.74-154.78, I<sup>2</sup> = 61%, P = 0.01) and NT-proBNP (MD: 947.45, 95% CI 98.97-1795.93, I<sup>2</sup> = 35%, P = 0.03). Similarly, low ASM was associated with significantly higher levels of BNP (MD: 118.95, 95% CI 46.91-191.00, I<sup>2</sup> = 93%, P < 0.01) and NT-proBNP (MD: 672.01, 95% CI 383.72-960.30, I<sup>2</sup> = 2%, P < 0.01). The quality of the included cohort studies was considered moderate, using the binary AXIS checklist and the Cochrane Tool to Assess the Risk of Bias in Cohort Studies.<h4>Conclusions</h4>In patients with HF, sarcopenia and reduced ASM are associated with considerably higher plasma levels of BNP and NT-proBNP. Future research is required to investigate whether sarcopenia may express dysregulated biomarkers of cardiac function.

Item Type:	Article
Uncontrolled Keywords:	BNP, Biomarkers, Cardiac function, Heart failure, NT-proBNP, Sarcopenia
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine
Depositing User:	Symplectic Admin
Date Deposited:	15 Apr 2024 09:55
Last Modified:	15 Apr 2024 10:07
DOI:	10.1007/s41999-024-00950-x
Open Access URL:	https://doi.org/10.1007/s41999-024-00950-x
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180333