Changes in immune cell subtypes during ageing.

Thin, Khin Aye, Cross, Andrew, Angsuwatcharakon, Phonthep, Mutirangura, Apiwat, Puttipanyalears, Charoenchai and Edwards, Steven W ORCID: 0000-0002-7074-0552 (2024) Changes in immune cell subtypes during ageing. Archives of gerontology and geriatrics, 122. p. 105376.

Access the full-text of this item by clicking on the Open Access link.

Official URL: http://dx.doi.org/10.1016/j.archger.2024.105376

Abstract

<h4>Background</h4>The immune system comprises many different types of cells, each with different functions and properties during immune defence. The numbers and types of immune cells in the circulation is highly dynamic and regulated by infections, ageing and certain types of cancers. It is recognised that immune function decreases during ageing, but the biological age at which these functional changes occur is variable, and how ageing affects the different sub-types of lymphocytes, monocytes and NK cells in the circulation is not fully defined.<h4>Methods</h4>In this study, we recruited 24 healthy volunteers over the age range of 23y to 89y and measured the numbers of different subclasses of circulating cells by immuno-phenotyping and flow cytometry.<h4>Results</h4>We show increased monocyte:lymphocyte ratios in a > 50y cohort and most T cell subsets were decreased, except for CD4+ cells, which were increased in this cohort. In addition, there was NK cell expansion and increased HLA-DR+ T cells, but decreased numbers of classical monocytes and increased numbers of CD4+ monocytes in this >50y cohort.<h4>Conclusions</h4>These data indicate that healthy ageing is associated with changes in both the major cell groups but also individual subclasses of cells, and these are likely to result from continuous immune challenge and impaired development.

Item Type:	Article
Uncontrolled Keywords:	Ageing, HLA-DR positive T lymphocytes, Immuno-phenotypes
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	16 Apr 2024 07:50
Last Modified:	16 Apr 2024 08:03
DOI:	10.1016/j.archger.2024.105376
Open Access URL:	https://doi.org/10.1016/j.archger.2024.105376
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180364