Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus.

Renaudineau, Yves, Charras, Amandine ORCID: 0000-0001-6760-5459, Natoli, Valentina, Fusaro, Mathieu, Smith, Eve MD ORCID: 0000-0002-8371-7597, Beresford, Michael W, Hedrich, Christian M ORCID: 0000-0002-1295-6179 and UK jSLE Cohort Study, (2024) Type I interferon associated epistasis may contribute to early disease-onset and high disease activity in juvenile-onset lupus. Clinical immunology (Orlando, Fla.), 262. p. 110194.

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Official URL: http://dx.doi.org/10.1016/j.clim.2024.110194

Abstract

Pathologic type I interferon (T1IFN) expression is a key feature in systemic lupus erythematosus (SLE) that associates with disease activity. When compared to adult-onset disease, juvenile-onset (j)SLE is characterized by increased disease activity and damage, which likely relates to increased genetic burden. To identify T1IFN-associated gene polymorphisms (TLR7, IRAK1, miR-3142/miR-146a, IRF5, IRF7, IFIH1, IRF8, TYK2, STAT4), identify long-range linkage disequilibrium and gene:gene interrelations, 319 jSLE patients were genotyped using panel sequencing. Coupling phenotypic quantitative trait loci (QTL) analysis identified 10 jSLE QTL that associated with young age at onset (<12 years; IRAK1 [rs1059702], TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760, rs3747517], STAT4 [rs3021866], TYK2 [rs280501], IRF8 [rs1568391, rs6638]), global disease activity (SLEDAI-2 K >10; IFIH1 [rs1990760], STAT4 [rs3021866], IRF8 [rs903202, rs1568391, rs6638]), and mucocutaneous involvement (TLR7 [rs3853839], IFIH1 [rs11891191, rs1990760]). This study suggests T1IFN-associated polymorphisms and gene:gene interrelations in jSLE. Genotyping of jSLE patients may allow for individualized treatment and care.

Item Type:	Article
Uncontrolled Keywords:	UK jSLE Cohort Study
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	17 Apr 2024 09:24
Last Modified:	17 Apr 2024 09:24
DOI:	10.1016/j.clim.2024.110194
Open Access URL:	https://doi.org/10.1016/j.clim.2024.110194
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180395