SnoRNAs in cardiovascular development, function, and disease.

Chabronova, Alzbeta ORCID: 0000-0002-9733-444X, Holmes, Terri L, Hoang, Duc M, Denning, Chris, James, Victoria, Smith, James GW and Peffers, Mandy J ORCID: 0000-0001-6979-0440 (2024) SnoRNAs in cardiovascular development, function, and disease. Trends in molecular medicine. S1471-4914(24)00059-5-S1471-4914(24)00059-5.

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Abstract

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication. In this review, we summarize and discuss key findings and outline the clinical potential of snoRNAs considering current challenges and gaps in the field of cardiovascular diseases (CVDs).

Item Type:	Article
Uncontrolled Keywords:	biomarker, cardiac fibrosis, cardiomyopathy, exercise, extracellular vesicles, snoRNA
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	17 Apr 2024 10:05
Last Modified:	17 Apr 2024 10:05
DOI:	10.1016/j.molmed.2024.03.004
Open Access URL:	https://doi.org/10.1016/j.molmed.2024.03.004
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180405