Kalakonda, Anita JM, Mahajan, Abhishek, Chow, Shien, Olsson-Brown, Anna C and Sacco, Joseph J
(2024)
Oestrogen Receptor Positive Metastatic Eccrine Porocarcinoma: A Case Report and Review of Anti-Oestrogen Therapy in Rare Cancers.
Case reports in oncology, 17 (1).
pp. 497-503.
Abstract
<h4>Introduction</h4>Rare cancers, in aggregate, represent a significant burden of disease in oncology and remain therapeutically challenging to manage due to a lack of clinical trials. Eccrine porocarcinoma is a rare cutaneous sweat-gland malignancy for which there remains no standard approach to metastatic disease.<h4>Case presentation</h4>We describe a patient diagnosed with metastatic disease, confirmed on bone biopsy; pathological analysis further revealed this was oestrogen receptor positive. She was commenced on the aromatase inhibitor letrozole, and denosumab, and showed a significant clinical and radiological response on bone scan within 7 months. At the time of report, over 2 years since commencing letrozole, she remains well with no evidence of progression.<h4>Conclusion</h4>Our experience adds to the literature suggesting anti-oestrogen therapy can have significant benefit in patients with ER-positive non-breast cancer and is in keeping with increasing interest in therapies agnostic to site of origin but guided by expression/mutation of oncogenic drivers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Anti-oestrogen therapy, Aromatase inhibitors, Case report, Eccrine porocarcinoma, Oestrogen receptor positive |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 23 Apr 2024 08:50 |
| Last Modified: | 23 Apr 2024 08:51 |
| DOI: | 10.1159/000535328 |
| Open Access URL: | https://doi.org/10.1159/000535328 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180527 |
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