Diarrhea Case Surveillance in the Enterics for Global Health <i>Shigella</i> Surveillance Study: Epidemiologic Methods.

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Atlas, Hannah E, Conteh, Bakary ORCID: 0000-0003-0701-2701, Islam, Md Taufiqul, Jere, Khuzwayo C ORCID: 0000-0003-3376-8529, Omore, Richard, Sanogo, Doh, Schiaffino, Francesca, Yousafzai, Mohammad Tahir ORCID: 0000-0001-8840-8323, Ahmed, Naveed, Awuor, Alex O et al (show 43 more authors) , Badji, Henry, Cornick, Jennifer, Feutz, Erika, Galagan, Sean R, Haidara, Fadima C, Horne, Bri'Anna, Hossen, Md Ismail, Hotwani, Aneeta, Houpt, Eric R, Jallow, Abdoulie F, Karim, Mehrab, Keita, Adama Mamby, Keita, Youssouf, Khanam, Farhana, Liu, Jie, Malemia, Thandizo, Manneh, Alhagie, McGrath, Christine J, Nasrin, Dilruba, Ndalama, Maureen, Ochieng, John Benjamin, Ogwel, Billy, Paredes Olortegui, Maribel, Zegarra Paredes, Loyda Fiorella, Pinedo Vasquez, Tackeshy, Platts-Mills, James A, Qudrat-E-Khuda, Syed, Qureshi, Sonia, Hasan Rajib, Md Nazmul, Rogawski McQuade, Elizabeth T, Sultana, Shazia, Tennant, Sharon M, Tickell, Kirkby D, Witte, Desiree, Peñataro Yori, Pablo, Cunliffe, Nigel A ORCID: 0000-0002-5449-4988, Hossain, M Jahangir, Kosek, Margaret N, Kotloff, Karen L, Qadri, Firdausi, Qamar, Farah Naz, Tapia, Milagritos D and Pavlinac, Patricia B (2024) Diarrhea Case Surveillance in the Enterics for Global Health <i>Shigella</i> Surveillance Study: Epidemiologic Methods. Open forum infectious diseases, 11 (Suppl ). S6-S16.

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Abstract

<h4>Background</h4><i>Shigella</i> is a leading cause of acute watery diarrhea, dysentery, and diarrhea-attributed linear growth faltering, a precursor to stunting and lifelong morbidity. Several promising <i>Shigella</i> vaccines are in development and field efficacy trials will require a consortium of potential vaccine trial sites with up-to-date <i>Shigella</i> diarrhea incidence data.<h4>Methods</h4>The Enterics for Global Health (EFGH) <i>Shigella</i> surveillance study will employ facility-based enrollment of diarrhea cases aged 6-35 months with 3 months of follow-up to establish incidence rates and document clinical, anthropometric, and financial consequences of <i>Shigella</i> diarrhea at 7 country sites (Mali, Kenya, The Gambia, Malawi, Bangladesh, Pakistan, and Peru). Over a 24-month period between 2022 and 2024, the EFGH study aims to enroll 9800 children (1400 per country site) between 6 and 35 months of age who present to local health facilities with diarrhea. <i>Shigella</i> species (spp.) will be identified and serotyped from rectal swabs by conventional microbiologic methods and quantitative polymerase chain reaction. <i>Shigella</i> spp. isolates will undergo serotyping and antimicrobial susceptibility testing. Incorporating population and healthcare utilization estimates from contemporaneous household sampling in the catchment areas of enrollment facilities, we will estimate <i>Shigella</i> diarrhea incidence rates.<h4>Conclusions</h4>This multicountry surveillance network will provide key incidence data needed to design <i>Shigella</i> vaccine trials and strengthen readiness for potential trial implementation. Data collected in EFGH will inform policy makers about the relative importance of this vaccine-preventable disease, accelerating the time to vaccine availability and uptake among children in high-burden settings.

Item Type:	Article
Uncontrolled Keywords:	Shigella, children, diarrhea, enterics, vaccine
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	30 Apr 2024 08:13
Last Modified:	30 Apr 2024 08:14
DOI:	10.1093/ofid/ofad664
Open Access URL:	https://doi.org/10.1093/ofid/ofad664
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180648