Prior, C 
ORCID: 0000-0002-5254-3205, Swales, H, Sharman, M, Reed, N, Bommer, N, Kent, A ORCID: 0000-0002-3680-5893, Glanemann, B, Clarke, K, Kortum, A, Kelly, D et al (show 35 more authors)
(2024)
Diagnostic findings in sinonasal aspergillosis in dogs in the United Kingdom: 475 cases (2011-2021).
The Journal of small animal practice.
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J of Small Animal Practice - 2024 - Prior - Diagnostic findings in sinonasal aspergillosis in dogs in the United Kingdom .pdf - Author Accepted Manuscript Download (1MB) | Preview |
Abstract
<h4>Objectives</h4>To describe the diagnostic tests used and their comparative performance in dogs diagnosed with sinonasal aspergillosis in the United Kingdom. A secondary objective was to describe the signalment, clinical findings and common clinicopathologic abnormalities in sinonasal aspergillosis.<h4>Materials and methods</h4>A multi-centre retrospective survey was performed involving 23 referral centres in the United Kingdom to identify dogs diagnosed with sinonasal aspergillosis from January 2011 to December 2021. Dogs were included if fungal plaques were seen during rhinoscopy or if ancillary testing (via histopathology, culture, cytology, serology or PCR) was positive and other differential diagnoses were excluded.<h4>Results</h4>A total of 662 cases were entered into the database across the 23 referral centres. Four hundred and seventy-five cases met the study inclusion criteria. Of these, 419 dogs had fungal plaques and compatible clinical signs. Fungal plaques were not seen in 56 dogs with turbinate destruction that had compatible clinical signs and a positive ancillary test result. Ancillary diagnostics were performed in 312 of 419 (74%) dogs with observed fungal plaques permitting calculation of sensitivity of cytology as 67%, fungal culture 59%, histopathology 47% and PCR 71%.<h4>Clinical significance</h4>The sensitivities of ancillary diagnostics in this study were lower than previously reported challenging the clinical utility of such tests in sinonasal aspergillosis. Treatment and management decisions should be based on a combination of diagnostics including imaging findings, visual inspection, and ancillary testing, rather than ancillary tests alone.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Infectious Diseases, 4 Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 30 Apr 2024 14:05 |
| Last Modified: | 09 May 2024 08:04 |
| DOI: | 10.1111/jsap.13736 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3180690 |
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