Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.

Dalby, Matthew J ORCID: 0000-0002-0528-3359, Pekovic-Vaughan, Vanja ORCID: 0000-0002-7876-652X, Shanley, Daryl P ORCID: 0000-0003-3096-6386, Swift, Joe ORCID: 0000-0002-5039-9094, White, Lisa J ORCID: 0000-0003-0571-999X and Canty-Laird, Elizabeth G ORCID: 0000-0001-5041-1316 (2024) Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community. BioEssays : news and reviews in molecular, cellular and developmental biology, 46 (5). e2300223-.

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Official URL: http://dx.doi.org/10.1002/bies.202300223

Abstract

Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three-dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age-associated pathology. The ECM 'Ageing Across the Life Course' interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field of ECM ageing. Here we report on a consultation at a joint meeting of ECMage and the Medical Research Council / Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, held in January 2023, in which delegates analysed the key questions and research opportunities in the field of ECM ageing. We examine fundamental biological questions, enabling technologies, systems of study and emerging in vitro and in silico models, alongside consideration of the broader challenges facing the field.

Item Type:	Article
Uncontrolled Keywords:	Extracellular Matrix, Animals, Humans, Aging, United Kingdom
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	03 May 2024 14:15
Last Modified:	10 May 2024 11:34
DOI:	10.1002/bies.202300223
Open Access URL:	https://doi.org/10.1002/bies.202300223
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3180773