OSTEORADIONECROSIS IN HEAD-AND-NECK CANCER HAS A DISTINCT GENOTYPE-DEPENDENT CAUSE

Lyons, Andrew J, West, Catharine M, Risk, Janet M ORCID: 0000-0002-8770-7783, Slevin, Nick J, Chan, Clara, Crichton, Siobhan, Rinck, Gabrielle, Howell, Dawn and Shaw, Richard J ORCID: 0000-0002-5157-4042 (2012) OSTEORADIONECROSIS IN HEAD-AND-NECK CANCER HAS A DISTINCT GENOTYPE-DEPENDENT CAUSE. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 82 (4). pp. 1479-1484.

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Abstract

<h4>Purpose</h4>We performed a case-control study to establish whether the development of osteoradionecrosis (ORN) was related to a variant allele substituting T for C at -509 of the transforming growth factor-β1 gene (TGF-β1).<h4>Patients and methods</h4>A total of 140 patients, 39 with and 101 without ORN, who underwent radiotherapy for head-and-neck cancer with a minimum of 2 years follow-up, were studied. None of the patients had clinical evidence of recurrence at this time. DNA extracted from blood was genotyped for the -509 C-T variant allele of the TGF-β1 gene.<h4>Results</h4>There were no significant differences in patient, cancer treatment, or tumor characteristics between the two groups. Of the 39 patients who developed ORN, 9 were homozygous for the common CC allele, 19 were heterozygous, and 11 were homozygous for the rare TT genotype. Of the 101 patients without ORN, the distribution was 56 (CC), 33 (CT), and 12 (TT). The difference in distribution was significant, giving an increased risk of ORN of 5.7 (95% CI, 1.7-19.2) for homozygote TT patients (p = 0.001) and 3.6 (95% CI, 1.3-10.0) for heterozygotes (p = 0.004) when compared with patients with the CC genotype. Postradiotherapy dentoalveolar surgery preceding the development of ORN was associated with the CC genotype (p = 0.02).<h4>Conclusions</h4>Our findings support the postulate that the development of ORN is related to the presence of the T variant allele at -509 within the TGF-β1 gene.

Item Type:	Article
Additional Information:	## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords:	Genotype, Head-and-neck cancer, Osteoradionecrosis, Post-radiotherapy, Transforming growth factor-beta 1, Variant allele
Subjects:	?? RC0254 ??
Divisions:	Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	08 Mar 2012 17:24
Last Modified:	15 Dec 2022 07:09
DOI:	10.1016/j.ijrobp.2011.05.016
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/5453