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Hong, W David, Benayoud, Farid, Nixon, Gemma L, Ford, Louise, Johnston, Kelly L, Clare, Rachel H, Cassidy, Andrew, Cook, Darren AN, Siu, Amy, Shiotani, Motohiro et al (show 24 more authors)
(2019)
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (4).
pp. 1414-1419.
Fernandez-Alvaro, Elena, Hong, W David, Nixon, Gemma L, O'Neil, Paul M and Calderon, Felix
(2016)
Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.
JOURNAL OF MEDICINAL CHEMISTRY, 59 (12).
pp. 5587-5603.
Lisauskaitė, Monika ORCID: 0009-0000-1364-5439, Nixon, Gemma L ORCID: 0000-0002-9730-0960, Woodley, Christopher M ORCID: 0000-0003-1311-4288, Berry, Neil G ORCID: 0000-0003-1928-0738, Coninckx, Andy ORCID: 0000-0001-9821-2746, Qie, L Charlie ORCID: 0009-0002-6325-7447, Leung, Suet C, Taramelli, Donatella ORCID: 0000-0001-5108-4492, Basilico, Nicoletta ORCID: 0000-0001-9030-1066, Parapini, Silvia ORCID: 0000-0003-2079-8892 et al (show 5 more authors)
(2024)
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>.
RSC chemical biology, 5 (1).
pp. 19-29.
McGillan, Paul, Berry, Neil G ORCID: 0000-0003-1928-0738, Nixon, Gemma L, Leung, Suet C, Webborn, Peter JH, Wenlock, Mark C, Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H, Cook, Darren A et al (show 6 more authors)
(2021)
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis.
ACS Medicinal Chemistry Letters, 12 (9).
pp. 1421-1426.
Woodley, Christopher M, Nixon, Gemma L, Basilico, Nicoletta, Parapini, Silvia, Hong, Weiqian David, Ward, Stephen A, Biagini, Giancarlo A, Leung, Suet C, Taramelli, Donatella, Onuma, Keiko et al (show 2 more authors)
(2021)
Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205.
ACS MEDICINAL CHEMISTRY LETTERS, 12 (7).
pp. 1077-1085.
Johnston, Kelly L, Cook, Darren AN, Berry, Neil G ORCID: 0000-0003-1928-0738, Hong, W David, Clare, Rachel H, Goddard, Megan, Ford, Louise, Nixon, Gemma L, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A et al (show 1 more authors)
(2017)
Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library.
SCIENCE ADVANCES, 3 (09).
eaao1551-.
Jeffreys, Laura N, Ardrey, Alison, Hafiz, Taghreed A, Dyer, Lauri-Anne, Warman, Ashley J, Mosallam, Nada, Nixon, Gemma L, Fisher, Nicholas E, Hong, W David, Leung, Suet C et al (show 11 more authors)
(2023)
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis.
ACS INFECTIOUS DISEASES, 9 (2).
pp. 221-238.
Clare, Rachel H, Bardelle, Catherine, Harper, Paul, Hong, W David, Borjesson, Ulf, Johnston, Kelly L, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren et al (show 21 more authors)
(2019)
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
NATURE COMMUNICATIONS, 10 (1).
11-.
O' Neill, Paul M, Sabbani, Sunil, Nixon, Gemma L, Schnaderbeck, Matthew, Roberts, Natalie L, Shore, Emma R, Riley, Christopher, Murphy, Ben, McGillan, Paul, Ward, Stephen A et al (show 2 more authors)
(2016)
Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials.
TETRAHEDRON, 72 (40).
pp. 6118-6126.
Nixon, Gemma L, McEntee, Laura, Johnson, Adam ORCID: 0000-0002-6684-3321, Farrington, Nikki, Whalley, Sarah, Livermore, Joanne, Natal, Cristien, Washbourn, Gina, Bibby, Jaclyn, Berry, Neil ORCID: 0000-0003-1928-0738 et al (show 6 more authors)
(2018)
Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease.
Antimicrobial Agents and Chemotherapy, 62 (4).
e01909-e01917.
O' Neill, Paul M, Stocks, Paul A, Sabbani, Sunil, Roberts, Natalie L, Amewu, Richard K ORCID: 0000-0002-4676-436X, Shore, Emma R, Aljayyoussi, Ghaith, Angulo-Barturen, Inigo, Belen, Maria, Jimenez-Diaz, et al (show 12 more authors)
(2018)
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
BIOORGANIC & MEDICINAL CHEMISTRY, 26 (11).
pp. 2996-3005.
Nixon, Gemma L ORCID: 0000-0002-9730-0960, Pidathala, Chandrakala, Shone, Alison E, Antoine, Thomas, Fisher, Nicholas, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A and Biagini, Giancarlo A
(2013)
Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era.
FUTURE MEDICINAL CHEMISTRY, 5 (13).
pp. 1573-1591.