Comparative genomics of <i>Staphylococcus capitis</i> reveals species determinants


Chong, Charlotte E ORCID: 0000-0001-8402-3936, Bengtsson, Rebecca J and Horsburgh, Malcolm James ORCID: 0000-0002-3806-0039 (2022) Comparative genomics of <i>Staphylococcus capitis</i> reveals species determinants. FRONTIERS IN MICROBIOLOGY, 13. 1005949-.

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Abstract

<i>Staphylococcus capitis</i> is primarily described as a human skin commensal but is now emergent as an opportunistic pathogen isolated from the bloodstream and prosthetic joint infections, and neonatal intensive care unit (NICU)-associated sepsis. We used comparative genomic analyses of <i>S. capitis</i> to provide new insights into commensal scalp isolates from varying skin states (healthy, dandruff lesional, and non-lesional), and to expand our current knowledge of the species populations (scalp isolates, <i>n</i> = 59; other skin isolates, <i>n</i> = 7; publicly available isolates, <i>n</i> = 120). A highly recombinogenic population structure was revealed, with genomes including the presence of a range of previously described staphylococcal virulence factors, cell wall-associated proteins, and two-component systems. Genomic differences between the two described <i>S. capitis</i> subspecies were explored, which revealed the determinants associated exclusively with each subspecies. The subspecies <i>ureolyticus</i> was distinguished from subspecies <i>capitis</i> based on the differences in antimicrobial resistance genes, β-lactam resistance genes, and β-class phenol soluble modulins and gene clusters linked to biofilm formation and survival on skin. This study will aid further research into the classification of <i>S. capitis</i> and virulence-linked phylogroups to monitor the spread and evolution of <i>S. capitis</i>.

Item Type: Article
Uncontrolled Keywords: Staphylococcus capitis, genome, scalp, dandruff, genomics, species determination, phenotypes
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 28 Oct 2022 10:05
Last Modified: 17 Oct 2023 13:01
DOI: 10.3389/fmicb.2022.1005949
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3165827
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