Chong, Charlotte E ORCID: 0000-0001-8402-3936, Bengtsson, Rebecca J and Horsburgh, Malcolm James ORCID: 0000-0002-3806-0039
(2022)
Comparative genomics of <i>Staphylococcus capitis</i> reveals species determinants.
FRONTIERS IN MICROBIOLOGY, 13.
1005949-.
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Abstract
<i>Staphylococcus capitis</i> is primarily described as a human skin commensal but is now emergent as an opportunistic pathogen isolated from the bloodstream and prosthetic joint infections, and neonatal intensive care unit (NICU)-associated sepsis. We used comparative genomic analyses of <i>S. capitis</i> to provide new insights into commensal scalp isolates from varying skin states (healthy, dandruff lesional, and non-lesional), and to expand our current knowledge of the species populations (scalp isolates, <i>n</i> = 59; other skin isolates, <i>n</i> = 7; publicly available isolates, <i>n</i> = 120). A highly recombinogenic population structure was revealed, with genomes including the presence of a range of previously described staphylococcal virulence factors, cell wall-associated proteins, and two-component systems. Genomic differences between the two described <i>S. capitis</i> subspecies were explored, which revealed the determinants associated exclusively with each subspecies. The subspecies <i>ureolyticus</i> was distinguished from subspecies <i>capitis</i> based on the differences in antimicrobial resistance genes, β-lactam resistance genes, and β-class phenol soluble modulins and gene clusters linked to biofilm formation and survival on skin. This study will aid further research into the classification of <i>S. capitis</i> and virulence-linked phylogroups to monitor the spread and evolution of <i>S. capitis</i>.
Item Type: | Article |
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Uncontrolled Keywords: | Staphylococcus capitis, genome, scalp, dandruff, genomics, species determination, phenotypes |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 28 Oct 2022 10:05 |
Last Modified: | 17 Oct 2023 13:01 |
DOI: | 10.3389/fmicb.2022.1005949 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3165827 |