Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas

Leather, Thomas, Jenkinson, Michael D ORCID: 0000-0003-4587-2139, Das, Kumar and Poptani, Harish ORCID: 0000-0002-0593-3235 (2017) Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas. METABOLITES, 7 (2). E29-.

Text 2017_glioma metabolites.docx - Author Accepted Manuscript Download (7MB)

Abstract

Mutations in the isocitrate dehydrogenase (IDH)1/2 genes are highly prevalent in gliomas and have been suggested to play an important role in the development and progression of the disease. Tumours harbouring these mutations exhibit a significant alteration in their metabolism resulting in the aberrant accumulation of the oncometabolite 2-hydroxygluarate (2-HG). As well as being suggested to play an important role in tumour progression, 2-HG may serve as a surrogate indicator of IDH status through non-invasive detection using magnetic resonance spectroscopy (MRS). In this review, we describe the recent efforts in developing MRS methods for detection and quantification of 2-HG in vivo and provide an assessment of the role of the 2-HG in gliomagenesis and patient prognosis.

Item Type:	Article
Uncontrolled Keywords:	isocitrate dehydrogenase, glioma, glioblastoma, 2-hydroxyglutarate, magnetic resonance spectroscopy
Depositing User:	Symplectic Admin
Date Deposited:	30 Jun 2017 10:18
Last Modified:	19 Jan 2023 07:01
DOI:	10.3390/metabo7020029
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3008249