Isoniazid acetylation phenotypes in the Sudanese population; findings and implications.

Ali, Monadil H, Alrasheedy, Alian A, Kibuule, Dan ORCID: 0000-0002-6908-2177, Hassali, Mohamed Azmi, Godman, Brian ORCID: 0000-0001-6539-6972, Abdelwahab, Mohammed F and Abbadi, Raef Y (2019) Isoniazid acetylation phenotypes in the Sudanese population; findings and implications. Journal of clinical tuberculosis and other mycobacterial diseases, 17. 100120-.

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Abstract

<h4>Background</h4>Isoniazid (INH) is the mainstay antimicrobial in the treatment of tuberculosis (TB). It is acetlylated in the liver to acetyl-INH. However, there is variation in rate of acetylation of INH among TB patients (i.e. fast, intermediate or slow acetylators) which impacts on the treatment outcomes.<h4>Aim</h4>The isoniazid acetylation phenotypes in the expatriate Sudanese population were determined to provide future guidance since TB is prevalent in Sudan.<h4>Methods</h4>A community-based trial among Sudanese expatriates in Saudi Arabia was undertaken to identify INH-acetylation phenotypes. After overnight fasting, a single dose of 200 mg of INH was given to the volunteers. Three hours later, 5 ml of blood were drawn from each volunteer and prepared for High-Performance Liquid Chromatography (HPLC) analysis. The main outcomes were INH and Acetyl-INH concentrations in plasma and the subsequent Acetyl-INH/INH metabolic ratio (MR).<h4>Results</h4>The findings suggest that slow acetylation is highly prevalent among the study participants (<i>n</i> = 43; 84.31%). Moreover, there was no statistically significant correlation between age and the MR (<i>r</i> = -0.18, <i>P</i> = 0.20). Further, there was no significant association between gender and the MR (<i>P</i> = 0.124). Similarly, no significant association was found between smoking habits and MR (<i>P</i> = 0.24).<h4>Conclusion</h4>Isoniazid phenotyping suggests predominantly slow acetylation among the Sudanese in this sample. The study found no statistically significant associations between the MR and age or gender or smoking.

Item Type:	Article
Uncontrolled Keywords:	Acetylation, Fast acetylators, INH, Isoniazid, Slow acetylators, Sudanese populations, Tuberculosis
Depositing User:	Symplectic Admin
Date Deposited:	10 Dec 2019 09:06
Last Modified:	19 Jan 2023 00:13
DOI:	10.1016/j.jctube.2019.100120
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3065667