Exploring the presence of markers of decidualization in the fallopian tubes: a systematic review

Aljassim, F, Georgopoulou, N ORCID: 0000-0002-1212-3185, Rigby, CH, Powell, SG ORCID: 0000-0002-5553-5286, Wyatt, JNR ORCID: 0000-0002-6456-0723, Hapangama, DK ORCID: 0000-0003-0270-0150 and Hill, CJ ORCID: 0000-0003-3831-4569 (2023) Exploring the presence of markers of decidualization in the fallopian tubes: a systematic review. BIOLOGY OF REPRODUCTION, 109 (2). pp. 125-136.

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Official URL: http://dx.doi.org/10.1093/biolre/ioad062

Abstract

The fallopian tubes (FTs) are part of the female upper genital tract. The healthy FT provides the biological environment for successful fertilization and facilitates the subsequent movement of the conceptus to the endometrial cavity. However, when the FT is damaged, as with salpingitis, pyosalpinx, and hydrosalpinx, it may increase the risk of an ectopic pregnancy, a life-threatening condition. Decidualization refers to a multifactorial process by which the endometrium changes to permit blastocyst implantation. The decidualization reaction is vital for endometrial receptivity during the window of implantation. To date, no comprehensive review that collates evidence on decidualization in the human FT has been conducted. Therefore, the aim of this review is to compile the current evidence on cellular decidualization occurring in the healthy and pathological FT in women of reproductive age. A literature search was conducted using five databases and identified 746 articles, 24 of which were analyzed based on inclusion and exclusion criteria. The available evidence indicates that the FT are able to undergo decidual changes under specific circumstances; however, the exact mechanism by which this occurs is poorly understood. Further research is needed to elucidate the mechanism by which decidualization can occur in the FT.

Item Type:	Article
Uncontrolled Keywords:	fallopian tubes, decidualization, implantation, ectopic pregnancy
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	06 Jun 2023 10:31
Last Modified:	29 Aug 2023 09:24
DOI:	10.1093/biolre/ioad062
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3170843