Evaluation of changes in corneal biomechanics after orthokeratology using Corvis ST

Zhang, PeiPei, Wu, JinFang, Jiang, Jun, Zhang, XinYu, Ran, ZiYing, Jiang, Fan, Zheng, XiaoBo, Wang, JunJie, Elsheikh, Ahmed ORCID: 0000-0001-7456-1749 and Bao, FangJun (2023) Evaluation of changes in corneal biomechanics after orthokeratology using Corvis ST. Contact Lens and Anterior Eye, 47 (1). p. 102100.

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Abstract

<h4>Purpose</h4>To investigate the alterations in corneal biomechanical metrics induced by orthokeratology (ortho-k) using Corvis ST and to determine the factors influencing these changes.<h4>Method</h4>A prospective observational study was conducted to analyze various Corvis ST parameters in 32 children with low to moderate myopia who successfully underwent ortho-k lens fitting. Corneal biomechanical measurements via Corvis ST were acquired at six distinct time points: baseline (pre) and 2 h (pos2h), 6 h (pos6h), and 10 h (pos10h) following the removal of the first overnight wear ortho-k, one week (pos1w) and one month (pos1m) subsequent to the initiation of ortho-k.<h4>Result</h4>Significant differences were observed in Corvis ST Biomechanical parameters DAR2, IIR, CBI, and cCBI post ortho-k intervention. The integration of covariates (CCT, SimK, and bIOP) mitigated the differences in DAR2, IIR, and cCBI, but not in CBI. Initially, the stiffness parameter at first applanation, SP-A1, did not demonstrate significant variations, but after adjusting for covariates, noticeable differences over time were observed. The Stress-Strain Indeces, SSIv1 and SSIv2, did not manifest considerable changes over time, irrespective of the adjustment for covariates. No significant disparities were identified among different ortho-k lens brands.<h4>Conclusion</h4>Corneal biomechanics remained consistent throughout the one-month period of ortho-k lens wear. The observed changes in Corvis ST parameters subsequent ortho-k are primarily attributable to alterations in corneal pachymetry and morphology, rather than actual alterations in corneal biomechanics. The stability of corneal biomechanics post ortho-k treatment suggests the safety of this approach for adolescents from a corneal biomechanics perspective.

Item Type:	Article
Uncontrolled Keywords:	Cornea, Humans, Corneal Topography, Tonometry, Ocular, Adolescent, Child, Corneal Pachymetry, Biomechanical Phenomena
Divisions:	Faculty of Science and Engineering > School of Engineering
Depositing User:	Symplectic Admin
Date Deposited:	11 Dec 2023 09:14
Last Modified:	02 Feb 2024 16:07
DOI:	10.1016/j.clae.2023.102100
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3177241