European' health care indicators and pancreatic cancer incidence and mortality: A mediation analysis of Eurostat data and Global Burden of Disease Study 2019.

Cucchetti, Alessandro ORCID: 0000-0001-5269-1964, Johnson, Philip ORCID: 0000-0003-1404-0209, Capurso, Gabriele, Crippa, Stefano, Pacilio, Carlo Alberto, Fabbri, Carlo, Falconi, Massimo ORCID: 0000-0001-9654-7243 and Ercolani, Giorgio ORCID: 0000-0003-4334-5167 (2023) European' health care indicators and pancreatic cancer incidence and mortality: A mediation analysis of Eurostat data and Global Burden of Disease Study 2019. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 23 (7). pp. 829-835.

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Abstract

<h4>Aim</h4>To highlight correlations existing between incidence and mortality of pancreatic cancer, and health care indicators in 36 European countries.<h4>Methods</h4>The Global Burden of Disease (GBD) and Eurostat databases were queried between 2004 and 2019. Incidence and mortality were age-standardized. From Eurostat, indicators regarding expenditure, hospital beds, medical technology, health personnel, physicians by medical specialty and unmet needs for medical examination were extracted. Correlations between GBD and Eurostat data were analysed through mediation analysis applying clustering for countries.<h4>Results</h4>Incidence increased by +0.6% per year (p = 0.001) and mortality by +0.3% (p = 0.001), being increasing for most of the European countries considered. Incidence and mortality were strongly positively correlated (p = 0.001). Higher current health expenditure, expenditure in inpatient curative care, the number of available beds, the number of computed tomography scan, magnetic resonance units, practising medical doctors were all related to higher incidence (p < 0.05), whereas the unmet need for medical examinations was related to lower incidence. When the mediator' effect of incidence was handled, these indicators, together with expenditure on outpatient curative cares, the number of pet scanners and of radiation therapy equipment, were related to lower mortality (p < 0.05).<h4>Conclusions</h4>Health care environment correlates with reported incidence and mortality of pancreatic cancer. This highlights both that ameliorated socio-economic societies suffer from higher incidence but lower mortality, as well as the epidemiological bias originating from countries' diagnostic ability.

Item Type:	Article
Uncontrolled Keywords:	Humans, Pancreatic Neoplasms, Incidence, Health Expenditures, Global Health, Global Burden of Disease, Mediation Analysis
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	22 Mar 2024 09:51
Last Modified:	22 Mar 2024 09:51
DOI:	10.1016/j.pan.2023.09.001
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3179706