Diagnostic accuracy of ultrasonography to detect hepatic and splenic lymphomatous infiltration in dogs and cats

Sumping, JC, Maddox, TW, Killick, D ORCID: 0000-0002-8787-7651 and Mortier, JR (2022) Diagnostic accuracy of ultrasonography to detect hepatic and splenic lymphomatous infiltration in dogs and cats. JOURNAL OF SMALL ANIMAL PRACTICE, 63 (2). pp. 113-119.

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Abstract

<h4>Objectives</h4>To determine the diagnostic accuracy of ultrasonography in the detection of lymphomatous infiltration of the liver and spleen in a population of dogs and cats with lymphoma. To determine if specific ultrasonographic features of the liver and spleen in dogs are associated with lymphomatous infiltration or a specific immunophenotype of multi-centric lymphoma.<h4>Materials and methods</h4>A blinded retrospective evaluation of ultrasonographic images of the liver and/or spleen in dogs and cats with cytologically or histologically confirmed lymphoma was performed by two board-certified veterinary radiologists.<h4>Results</h4>A total of 161 animals met the inclusion criteria, comprising 132 dogs and 29 cats. Ultrasonography had a sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 16.7%, 91.0%, 55.9%, 62.5% and 55.0% for the detection of lymphomatous infiltration of the liver, and 73.1%, 93.9%, 82.6%, 93.4% and 74.7% for the spleen. In dogs, an ultrasonographically normal liver was associated with not having lymphomatous infiltration, leopard-spotted splenic parenchyma and splenomegaly were independently associated with lymphomatous infiltration and leopard-spotted splenic parenchyma was also associated with the B cell immunophenotype of multi-centric lymphoma.<h4>Clinical significance</h4>Ultrasonography of the spleen and liver is specific but not sensitive in the detection of lymphomatous infiltration. A leopard-spotted splenic parenchyma in dogs is highly specific for lymphomatous infiltration and in this population predicted a specific immunophenotype of multi-centric lymphoma.

Item Type:	Article
Uncontrolled Keywords:	Liver, Animals, Dogs, Cats, Lymphoma, Liver Neoplasms, Splenic Neoplasms, Cat Diseases, Dog Diseases, Ultrasonography, Sensitivity and Specificity, Retrospective Studies
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User:	Symplectic Admin
Date Deposited:	29 Nov 2021 10:59
Last Modified:	18 Jan 2023 21:23
DOI:	10.1111/jsap.13438
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3144154